Category: Genetic Factors

Neural basis of Huntington disease

Huntingtons disease is a neurodegenerative disorder caused by a mutant gene that produces a toxic protein damaging nerve cells in the brain that leads to a decline in cognitive and motor function. This post explores the latest research on the neural basis of HD, brain regions affected, pathophysiology of neuronal death, and molecular mechanisms. Additionally, we will delve into potential treatments, such as gene therapy or stem cell therapy, that are being investigated to improve patient quality of life.

Neuroscience Neurodegenerative Disorders Genetics Molecular Biology Pathology Treatment Animal Models Research Ethics.

Neural basis of Tourette syndrome

Tourette Syndrome (TS) is a complex neuropsychiatric disorder characterized by repetitive, involuntary movements and sounds known as tics. The neural basis of Tourette syndrome is incredibly complex and involves a range of brain regions and neural circuits. Several theories attempt to explain the underlying causes of TS, including abnormalities in dopamine, glutamate, and GABA systems. Neuroimaging studies have shown abnormal activation in prefrontal, striatal, and thalamic regions. Additionally, the basal ganglia and CSTC circuits are thought to play a critical role in the onset and maintenance of tics. This post explores the neural basis of Tourette syndrome and its underlying causes, highlighting potential applications and challenges in understanding TS.

Neuroscience Neurodevelopmental Disorders Tourette Syndrome Basal Ganglia Prefrontal Cortex CSTC Circuits Genetic Factors Deep Brain Stimulation Treatment