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Category: Basal Ganglia

Neural basis of Tourette syndrome

Tourette Syndrome (TS) is a complex neuropsychiatric disorder characterized by repetitive, involuntary movements and sounds known as tics. The neural basis of Tourette syndrome is incredibly complex and involves a range of brain regions and neural circuits. Several theories attempt to explain the underlying causes of TS, including abnormalities in dopamine, glutamate, and GABA systems. Neuroimaging studies have shown abnormal activation in prefrontal, striatal, and thalamic regions. Additionally, the basal ganglia and CSTC circuits are thought to play a critical role in the onset and maintenance of tics. This post explores the neural basis of Tourette syndrome and its underlying causes, highlighting potential applications and challenges in understanding TS.